Genetics and Genomics

Credits
6
Types
Compulsory
Requirements
This subject has not requirements , but it has got previous capacities
Department
UB
This course covers the basic principles of genetic analysis and genomics, with a especial focus on genetic diseases.

Teachers

Person in charge

Others

Weekly hours

Theory
2
Problems
1.5
Laboratory
0.5
Guided learning
0
Autonomous learning
6

Competences

Learning Outcomes

Knowledge

  • K1 - Recognize the basic principles of biology, from cellular to organism scale, and how these are related to current knowledge in the fields of bioinformatics, data analysis, and machine learning; thus achieving an interdisciplinary vision with special emphasis on biomedical applications.
  • K6 - Recognize the ethical problems that arise from advances in the knowledge and in the application of biological concepts and their computational processing.

    • Skills

  • S2 - Computationally analyze DNA, RNA and protein sequences, including comparative genome analyses, using computation, mathematics and statistics as basic tools of bioinformatics.
  • S6 - Identify and interpret relevant data, within the area of study, to make judgments that include social, scientific or ethical reflections.
  • S8 - Make decisions, and defend them with arguments, in the resolution of problems in the areas of biology, as well as, within the appropriate fields, health sciences, computer sciences and experimental sciences.
  • S9 - Exploit biological and biomedical information to transform it into knowledge; in particular, extract and analyze information from databases to solve new biological and biomedical problems.

    • Competences

  • C6 - Detect deficiencies in the own knowledge and overcome them through critical reflection and the choice of the best action to expand this knowledge.
  • C7 - Detect, from within the scope of the degree, inequalities based on sex and gender in society; integrate the different needs and preferences based on sex and gender in the design of solutions and problem solving.

    • Objectives

    1. Ability to describe the molecular and cellular organization and function of hereditary material
      Related competences: C6, K1,
    2. Understanding the mechanisms of inheritance and the genetic basis of disease.
      Related competences: C7, K1, K6, S6, C6,
    3. To choose and apply instrumental, analytical, molecular and informatics techniques
      Related competences: C6, C7, S2, S6, S8, S9,
    4. Analyze a genetic problem and search for tools to address and solve it.
      Related competences: C6, C7, K1, K6, S2, S6, S8, S9,

    Contents

    1. Genes and genomes
      Structure of genomes
    2. The human genome
      Composition and function
    3. Genetic variation
      Functional annotation and interpretation
    4. Mechanisms of genetic trasnmission
      Basics of genetic inheritance
    5. Medical genetics
      Rare and complex disorders
    6. Gene expression
      Transcriptomics

    Activities

    Activity Evaluation act


    Theoretical expository lectures



    Theory
    25h
    Problems
    0h
    Laboratory
    0h
    Guided learning
    0h
    Autonomous learning
    45h

    Practical laboratory sessions



    Theory
    0h
    Problems
    22.9h
    Laboratory
    7.1h
    Guided learning
    0h
    Autonomous learning
    5h

    Problems solving sessions



    Theory
    0h
    Problems
    0h
    Laboratory
    0h
    Guided learning
    0h
    Autonomous learning
    40h

    Mid term exam


    Objectives: 1 2 3 4
    Week: 1
    Theory
    0h
    Problems
    0h
    Laboratory
    0h
    Guided learning
    0h
    Autonomous learning
    0h

    Final exam


    Objectives: 1 2 3 4
    Week: 1
    Theory
    0h
    Problems
    0h
    Laboratory
    0h
    Guided learning
    0h
    Autonomous learning
    0h

    Teaching methodology

    Classroom teaching will consist of lectures, seminars and practical computer and laboratory sessions.

    Evaluation methodology

    In order to successfully complete the course, the student must:

    Get a score higher than 3.5 in the weighted average of the two individual in-personl evaluations (final exam 90%, midterm exam 10%).
    Get a final grade > 5/10
    Participate in all the evaluated activities
     
    The final grade will be calculated as follows (final maximum grade is 10):
     
    4 points: final exam
    1 point: mid-term exam
    2 points: evaluation of the problems sessions (seminars)
    2 points: evaluation of practical sessions.
    1 point: weekly exercises.

    The re-evaluation exam replaces the final exam grade.

    Bibliography

    Basic