Requisitos
Esta asignatura no tiene requisitos
This course covers the basic principles of cell structure and function, mainly in and eukaryotic cells. Subjects include the cytoskeleton, the plasma membrane and extracellular matrix, transport, the nucleus, ER, Golgi apparatus, cell communication, stem cells, cell death, cancer and organization of tissues. The functioning of particular cell types will be addressed. The course will also emphasize methods for imaging cells and their components and the computational methods to perform data analysis of images. Integration of the physiological information as well as to reinforce the interest of the students in the use of bioinformatics applications as a necessary tool to approach complex biological and physiological process. The course will also introduce students to the basic principles of light microscopy and the quantitative analysis of fluorescence microscopy images and their application in the study of the cell¿s biology.
Profesorado
Responsable
-
Berta Alsina Español (
)
-
Oriol Gallego Moli (
)
Otros
-
Ricardo Ausencio Camacho Novoa (
)
-
Trifone Pastore (
)
-
Xavier Sanjuan Samarra (
)
Resultados de aprendizaje
Resultados de aprendizaje
Conocimientos
-
K1 - Reconocer los principios básicos de la biología, desde la escala celular a la de organismo, y cómo estos se relacionan con los conocimientos actuales en los campos de la bioinformática, del análisis de datos y del aprendizaje automático; alcanzando así una visión interdisciplinar con especial énfasis en aplicaciones biomédicas.
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K6 - Reconocer los problemas éticos a los que da lugar el progreso en el conocimiento y la aplicación de los conceptos biológicos y su proceso computacional.
Habilidades
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S6 - Identificar e interpretar los datos relevantes, dentro del área de estudio, para emitir juicios que incluyan reflexiones de índole social, científica o ética.
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S8 - Enfrentarse a la toma de decisiones, y defenderlas con argumentos, en la resolución de problemas de las áreas de biología, así como, dentro de los ámbitos adecuados, las ciencias de la salud, las ciencias de la computación y las ciencias experimentales.
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S9 - Explotar información biológica y biomédica para transformarla en conocimiento; en particular, extraer y analizar información de bases de datos para resolver nuevos problemas biológicos y biomédicos.
Competencias
-
C6 - Detectar deficiencias en el propio conocimiento y superarlas mediante la reflexión crítica y la elección de la mejor actuación para ampliar este conocimiento.
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C7 - Detectar, desde el propio ámbito de la titulación, las desigualdades por razón de sexo y género en la sociedad; integrar las diferentes necesidades y preferencias por razón de sexo y de género en el diseño de soluciones y resolución de problemas.
Objetivos
-
Introduce the student into the world of Cellular Biology and Physiological phenomenon, to understand the inside world of cells and their organization of higher order systems.
Competencias relacionadas:
C6,
K1,
S6,
S8,
S9,
-
Teach to student the bases of basic research in cellular biology and help them reaching the correct conclusions from their experimental results.
Competencias relacionadas:
C6,
K1,
S6,
S8,
C7,
S9,
-
To provide students the basic theoretical basic fundamentals, competences and practical skills that allow them to approach light microscopy imaging.
Competencias relacionadas:
K1,
K6,
S6,
S8,
S9,
Contenidos
-
BASICS OF EUKARYOTE CELL: FROM STRUCTURE TO ORGANIZATION
Plasma membrane, transport and ECM. Cell adhesion, the cytoskeleton and the nucleus. The Endoplasmic Reticulum and Golgi. The nucleus and gene regulation. Cellular Communication between animal cells and particular pathways. Pluripotency, Stem Cells and Cancer. Cell death and senescence.
-
Principles of light microscopy and image analysis in Cell biology
Principles Microscopy I and II. Imaging subcellular structures I and II. Limit of Resolution.
Actividades
Actividad
Acto evaluativo
Theoretical Lessons
Objetivos:
1
2
3
Seminars
Objetivos:
1
2
3
Laboratory practicals
Objetivos:
1
2
3
Cell Biology Presentations
Objetivos:
1
2
Semana:
1
Continuous assessment of Cell Biology
Objetivos:
1
2
Semana:
1
Microscopy integration of concepts
Objetivos:
2
3
Semana:
1
Oral exam about the Macro
Objetivos:
2
3
Semana:
1
Final exam
Objetivos:
1
2
3
Semana:
1
Metodología docente
The methodology combines Theoretical lessons, Seminars (with 20-30 students in each group) and Laboratory Practicals (the class is divided in 3 symmetric groups). We will follow a continuous assessment through the delivery of group projects, oral presentations and other evaluations activities. Ultimately, the students knowledge and skills will be evaluated with a final exam.
Método de evaluación
A series of exams are used to measure the success in meeting the course learning objectives. In order to successfully complete this course, the student must pass at least with 5 points over 10. All exams are compulsory.
The final grade of the students will result from the sum of Cell Biology (up to 6 points) and Microscopy and Image Analysis (up to 4 points). Each of the grades will result from:
Cell Biology:
Essay fo cell biology (20%)
Exam of Laboratory practices- (10%)
Oral Presentations (20%)
Final Exam (Pem and short questions) (50%)
Microscopy and Image Analysis:
Macro for image analysis (70%). This is the result of the sum of Group Macro (up to 3 points), Oral exam (up to 4 points)
and Autoevaluation (up to 3 points)
Integration of Concepts (10%)
Evaluation on Principles of microscopy (20%)
The average grade of the Final exam and the Evaluation on Principles of microscopy must be at least of 3.5 (that is, (0.5*6*EF+0.2*4*EP)/(0.5*6+0.2*4) must be at least 3.5) to consider the rest of the assessment items in the final grade.
Bibliografía
Básica:
-
Molecular Biology of the Cell -
ALBERTS, B.; JOHNSON, A.; LEWIS, J.; RAFF, M.; ROBERTS, K.; WALTER, P. ,
Garland Science, , 2008.
-
The Cell. A molecular approach -
COOPER, G.M. i HAUSMAN, R.E. ,
Washington D.C. and Sunderland, 2007.
-
Histología. Texto y Atlas. -
GARTNER, L. P.; HIATT, J. L. ,
McGraw-Hill Interamericana, 2007.
-
Vander¿s Human Physiology -
WIDMAIER, E.P.; RAFF, H. and STRANG K.T. ,
McGraw Hill, 2011.
-
Bioimage Data Analysis -
MIURA K. ,
Wiley-VCH, 2016.